Paolo Curatolo Selected Research

trans-sodium crocetinate (crocetin)

3/2022	Current role of surgery for tuberous sclerosis complex-associated epilepsy.
1/2022	Down-regulation of the brain-specific cell-adhesion molecule contactin-3 in tuberous sclerosis complex during the early postnatal period.
1/2022	Sleep disorders and neuropsychiatric disorders in a pediatric sample of tuberous sclerosis complex: a questionnaire-based study.
1/2022	Association of Early MRI Characteristics With Subsequent Epilepsy and Neurodevelopmental Outcomes in Children With Tuberous Sclerosis Complex.
1/2022	Questionnaire-based assessment of sleep disorders in an adult population of Tuberous Sclerosis Complex.
1/2022	Evolution of electroencephalogram in infants with tuberous sclerosis complex and neurodevelopmental outcome: a prospective cohort study.
1/2022	Genetic pathogenesis of the epileptogenic lesions in Tuberous Sclerosis Complex: Therapeutic targeting of the mTOR pathway.
12/2021	Adjunctive everolimus therapy for tuberous sclerosis complex-associated refractory seizures: Results from the postextension phase of EXIST-3.
11/2021	Neuroimaging and genetic characteristics of malformation of cortical development due to mTOR pathway dysregulation: clues for the epileptogenic lesions and indications for epilepsy surgery.
10/2021	MicroRNA-34a activation in tuberous sclerosis complex during early brain development may lead to impaired corticogenesis.

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Paolo Curatolo Research Topics

Disease

79	Tuberous Sclerosis (Bourneville's Disease) 03/2022 - 01/2002
53	Epilepsy (Aura) 03/2022 - 01/2008
46	Seizures (Absence Seizure) 01/2022 - 04/2005
28	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 12/2022 - 12/2006
20	Autism Spectrum Disorder 01/2022 - 10/2010
16	Autistic Disorder (Autism) 11/2020 - 03/2004
16	Astrocytoma (Pilocytic Astrocytoma) 01/2019 - 12/2012
12	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 02/2009
12	Angiomyolipoma 01/2020 - 06/2008
9	Drug Resistant Epilepsy 01/2022 - 02/2009
8	Neurodevelopmental Disorders 10/2021 - 01/2012
8	Infantile Spasms (West Syndrome) 01/2021 - 04/2006
7	Intellectual Disability (Idiocy) 01/2022 - 09/2006
7	Neoplasms (Cancer) 01/2021 - 08/2011
5	Lymphangioleiomyomatosis (Lymphangiomyomatosis) 01/2019 - 09/2013
5	Brain Diseases (Brain Disorder) 05/2018 - 02/2009
4	Hamartoma 01/2018 - 08/2011
4	Hydrocephalus (Hydrocephaly) 01/2017 - 01/2011
4	Lennox Gastaut Syndrome 11/2014 - 11/2010
3	Tics (Tic) 02/2022 - 12/2006
3	Tourette Syndrome (Tourette's Syndrome) 02/2022 - 12/2006
3	Sleep Wake Disorders 01/2022 - 02/2020
3	Focal Cortical Dysplasia 11/2021 - 11/2007
3	Headache (Headaches) 05/2021 - 05/2006
3	Epileptic Syndromes 01/2021 - 06/2010
3	Cognitive Dysfunction 10/2020 - 07/2004
3	Rett Syndrome (Rett's Disorder) 01/2020 - 02/2017
3	Rhabdomyoma 01/2017 - 09/2013
3	Abdominal Pain (Pain, Abdominal) 01/2015 - 09/2009
3	Absence Epilepsy (Childhood Absence Epilepsy) 03/2014 - 11/2008
3	Partial Epilepsies (Epilepsy, Partial) 12/2013 - 02/2009
3	Oppositional Defiant Disorder 11/2009 - 12/2006
2	Anxiety Disorders (Anxiety Disorder) 02/2022 - 11/2019
2	Rare Diseases (Rare Disease) 01/2021 - 11/2014
2	Skin Manifestations 09/2013 - 12/2012
2	Syncope (Fainting) 05/2011 - 11/2010
2	Juvenile Myoclonic Epilepsy 06/2010 - 01/2008
2	Rolandic Epilepsy (Centrotemporal Epilepsy) 06/2010 - 07/2004
2	Cerebral Palsy (Spastic Diplegia) 06/2010 - 02/2007
2	Spasm (Spasms) 02/2010 - 11/2007
2	Down Syndrome (Down's Syndrome) 08/2004 - 11/2003
2	Dementia (Dementias) 08/2004 - 11/2003
1	Learning Disabilities (Learning Disability) 12/2022
1	Neurocutaneous Syndromes (Phakomatoses) 03/2022
1	Tic Disorders (Tic Disorder) 02/2022
1	Sleepiness 01/2022
1	Hemimegalencephaly 11/2021
1	Sclerosis 11/2021
1	Specific Language Disorder 01/2021
1	Language Development Disorders (Semantic-Pragmatic Disorder) 01/2021
1	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 01/2021
1	Neurologic Manifestations (Neurological Manifestations) 01/2021
1	Disease Progression 01/2021

Drug/Important Bio-Agent (IBA)

68	trans-sodium crocetinate (crocetin)IBA 03/2022 - 01/2006
24	Pharmaceutical PreparationsIBA 02/2021 - 01/2002
23	Everolimus FDA Link 01/2022 - 08/2011
19	Anticonvulsants (Antiepileptic Drugs)IBA 01/2021 - 04/2005
12	Vigabatrin FDA Link 01/2021 - 04/2006
10	MTOR InhibitorsIBA 01/2022 - 11/2010
10	Biomarkers (Surrogate Marker)IBA 01/2022 - 08/2009
10	Biological ProductsIBA 01/2022 - 03/2004
10	TOR Serine-Threonine KinasesIBA 01/2021 - 01/2013
8	Methylphenidate (Ritalin)FDA LinkGeneric 10/2018 - 07/2009
7	Sirolimus (Rapamycin)FDA Link 01/2022 - 02/2009
7	rufinamide FDA Link 01/2018 - 11/2010
6	Atomoxetine Hydrochloride (Strattera)FDA LinkGeneric 01/2015 - 07/2009
5	Proteins (Proteins, Gene)FDA Link 10/2020 - 09/2006
5	Levetiracetam (Keppra)FDA LinkGeneric 03/2014 - 01/2008
4	Topiramate (Topamax)FDA LinkGeneric 01/2018 - 05/2006
4	Serotonin (5 Hydroxytryptamine)IBA 03/2011 - 03/2007
3	Tryptophan (L-Tryptophan)FDA Link 05/2021 - 02/2020
3	MelatoninIBA 05/2021 - 03/2015
3	Valproic Acid (Depakote)FDA LinkGeneric 01/2018 - 06/2013
3	Retinaldehyde (Retinal)IBA 01/2018 - 04/2014
2	Vitamin B 6IBA 02/2022 - 02/2020
2	Mechanistic Target of Rapamycin Complex 1IBA 10/2021 - 01/2017
2	arylesteraseIBA 01/2021 - 12/2010
2	gamma-Aminobutyric Acid (GABA)IBA 03/2019 - 11/2007
2	lipoarabinomannan (LAM)IBA 01/2019 - 01/2018
2	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 01/2012
2	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 02/2018 - 01/2015
2	Phenobarbital (Luminal)FDA Link 01/2018 - 06/2012
2	perampanelIBA 01/2018 - 06/2017
2	Oxcarbazepine (Trileptal)FDA LinkGeneric 01/2018 - 06/2013
2	Lamotrigine (Lamictal)FDA LinkGeneric 03/2014 - 07/2004
2	Antipsychotic Agents (Antipsychotics)IBA 09/2013 - 02/2013
1	Eicosapentaenoic AcidIBA 12/2022
1	gamma-Linolenic AcidIBA 12/2022
1	Food Additives (Food Additive)IBA 12/2022
1	Fatty Acids (Saturated Fatty Acids)IBA 12/2022
1	Docosahexaenoic AcidsIBA 12/2022
1	theanineIBA 02/2022
1	Cell Adhesion MoleculesIBA 01/2022
1	Vitamin B Complex (B Vitamins)IBA 05/2021
1	MagnesiumIBA 05/2021
1	SteroidsIBA 01/2021

Therapy/Procedure

29	Therapeutics 01/2022 - 05/2006
8	Drug Therapy (Chemotherapy) 01/2022 - 01/2009
2	Cesarean Section (Caesarean Section) 06/2014 - 02/2007
1	Treatment Delay 01/2021